Sunan Samfurin:Tangerinefoda
Wani Suna: Citrus aurantium tsantsa,Citrus bawon Citrus,Citrus polymethoxyflavones tsantsa,Citrus bioflavonoid tsantsa
Tushen Botanical:Tangerines; Deuterophoma traceipila; Fortunella japonica
Sunan Latin: Syringa reticulata (Blume) Hara var. amurensis (Rupr.) Pringle
Gwaji: 10%, 98%, 99%Tangerine
Lambar CAS:481-53-8
Launi: Foda fari mai ƙamshi da ɗanɗano na musamman
Matsayin GMO: Babu GMO
Shiryawa: a cikin ganga na fiber 25kgs
Ajiya: A ajiye akwati a wuri mai sanyi da bushewa, a ajiye shi nesa da haske mai ƙarfi
Rayuwar Shiryayye: Watanni 24 daga ranar samarwa
Sunan Samfurin: Tangerine
Lambar CAS: 481-53-8
Sunan da aka rubuta: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Synonyms: NSC 53909, NSC 618905, Ponkanetin, Tangeritin
Tsarin Kwayoyin Halitta: C₂₀H₂₀O₇
Nauyin kwayoyin halitta: 372.4
Tsarkakakke: ≥98%
Bayyanar: Farin foda
Narkewa:
- Mai narkewa a cikin sinadarai masu narkewa kamar ethanol, DMSO2, da dimethyl formamide (DMF)
- Yana narkewa sosai a cikin buffers na ruwa
- Domin samun isasshen narkewa a cikin ruwan da ke cikin tangeretin, ya kamata a fara narkar da tangeretin a cikin DMF sannan a narkar da shi da ruwan da aka zaɓa.
- Narkewa a cikin DMF-PBS (pH 7.2) kusan 0.15 mg/ml ne
Yanayin Ajiya:
- Ajiye a -20°C har zuwa shekaru 3
- Don samun ruwan sha, a adana a -80°C har zuwa kwana 2
Kwanciyar hankali:
- Barga na akalla shekaru 4 a ƙarƙashin yanayin ajiya mai kyau
Bayani:
Tangerin wani flavone ne mai polymethoxylated wanda aka ware daga bawon 'ya'yan itacen citrus, musamman ma tangerines da mandarin. Yana da sinadarai na halitta waɗanda ke da ayyuka daban-daban na halitta, waɗanda suka haɗa da hana kumburi, hana tsufa, da kuma hana ciwon daji. An nuna cewa Tangerin yana hana hanyoyin sigina kamar ERK, p38 MAPK, JNK, da Akt, waɗanda ke da hannu a yaduwar ƙwayoyin cutar kansa da kuma rayuwa.
Ayyukan Halittu da Aikace-aikace:
- Tasirin Yaƙi da Ciwon daji:
- Tangerin yana hana ci gaban ƙwayoyin cutar kansar nono (misali, T47D) da ƙwayoyin cutar kansar huhu (misali, A549) ta hanyar rage phosphorylation na ERK da toshe kunna p38 MAPK, JNK, da Akt.
- Yana wayar da kan ƙwayoyin cutar kansar ƙwai na ɗan adam waɗanda ke jure wa cisplatin ta hanyar rage tsarin siginar PI3K/Akt, yana ƙara apoptosis da kuma dakatar da zagayowar ƙwayoyin halitta.
- Tangeretin kuma yana haifar da dakatar da zagayowar ƙwayoyin G1 amma ba apoptosis a cikin ƙwayoyin cutar kansar nono da hanji na ɗan adam ba.
- Tasirin Kariya daga Kumburi da Jijiyoyin Jiki:
- Tangerin yana daidaita siginar NF-κB, yana rage kumburi da damuwa ta oxidative a cikin nau'ikan cututtuka daban-daban, gami da raunin koda da kumburin jijiyoyi.
- Yana nuna tasirin hana kumburi ta hanyar hana kunna ƙwayoyin microglial a cikin al'adun da aka motsa ta hanyar lipopolysaccharide.
- Tangerin yana da ƙarfi wajen hana Notch-1, yana nuna tasirin kariya daga jijiyoyi da kuma hana kumburi a cikin nau'ikan cututtuka da dama.
- Sauran Aikace-aikace:
- An nuna cewa Tangeretin yana kare ƙwayoyin epithelial na koda daga gubar da cisplatin ke haifarwa ta hanyar rage damuwa da kumburi.
- Haka kuma yana iya samun damar magance ciwon suga saboda tasirinsa na antioxidant da anti-inflammatory.
Amfani da Tsaro:
- An yi nufin wannan samfurin don amfani da bincike kawai kuma bai dace da ganewar asali ko magani na asibiti ba.
- Koyaushe a bi shawarwarin da aka bayar na adanawa da sarrafa kayan don kiyaye amincin su da amincin su.
Bayanin Mai Bayarwa:
- Alamar: Cayman Chemical
- Lambar Samfura: 10009911
- Bayanan da aka ƙayyade a cikin rukuni: Kowace rukuni tana tare da takardar shaidar bincike (COA) wanda ke ba da cikakkun sakamakon bincike.
Nassoshi:
- Bayanin Samfurin Sinadaran Cayman
- Aragon et al. (2009) akan tasirin anti-cancer tangeretin
- Hirano da abokan aikinsa (1995) kan aikin maganin cutar sankarar jini ta tangeretin.
- Lee et al. (2016) kan hanyoyin hana kumburi da kuma maganin hana tsufa na tangeretin a cikin ƙwayoyin microglia.
Kammalawa:
Tangerin wani sinadari ne na halitta mai amfani da yawa kuma mai ƙarfi wanda ke da ayyuka daban-daban na halitta, wanda hakan ya sa ya zama kayan aiki mai mahimmanci a binciken cutar kansa, nazarin kumburi, da kuma kare jijiyoyi. Tsarkakensa, kwanciyar hankali, da kuma narkewarsa a cikin sinadarai daban-daban sun sa ya dace da aikace-aikacen gwaji iri-iri.
