Oleoylethanolamide (OEA)

Sunan samfur:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Wani suna:N- (2-Hydroxyethyl) -9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide, N- (2-Hydroxyethyl)oleamide
CAS No:111-58-0
Tsarin Halitta:C₂₀H₃₉NO₂
Nauyin Kwayoyin Halitta:325.5
Gwajin:90%,95%, 85% min
Bayyanar:kirim mai launin foda

Oleoylethanolamidewani sabon abu ne ga kasuwar abinci mai gina jiki a matsayin sanannen ƙarin kayan abinci na abinci da ake amfani da shi a cikin dabarun asarar nauyi.Yawancin magoya bayan ginin jiki suna tattaunawa game da oleoylethanolamide akan reddit da sauran hanyoyin sadarwar zamantakewa.

Oleoylethanolamide shine metabolite na halitta na oleic acid da aka yi a cikin ƙananan hanji cikin jikin mutum.Yana faruwa ne a zahiri, kuma masana suna kiransa "endogenous".

OEA ita ce mai daidaita yanayin ci, nauyi da cholesterol.Metabolite ne na halitta wanda aka yi shi da ɗan kadan a cikin ƙaramin hanjin ku.OEA na taimakawa wajen daidaita yunwa, nauyi, kitsen jiki da cholesterol ta hanyar ɗaure ga mai karɓa da aka sani da PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).A zahiri, OEA yana ƙara haɓakar kitsen jiki kuma yana gaya wa kwakwalwar ku cewa kun cika kuma lokaci ya yi da za ku daina cin abinci.Hakanan an san OEA don ƙara kashe kuɗin kalori marasa motsa jiki.

Tarihin Oleylethanolamide

An gano ayyukan nazarin halittu na Oleoylethanolamide tun shekaru 50 da suka gabata.Kafin 2001, babu bincike da yawa akan OEA.Duk da haka, a wannan shekarar, masu binciken Mutanen Espanya sun karya lipid kuma sun yi nazarin yadda ake yin shi, inda ake amfani da shi da kuma abin da yake aikatawa.Sun gwada tasirin OEA akan kwakwalwa (na berayen) ta hanyar yi masa allura kai tsaye zuwa cikin ventricles na kwakwalwa.Ba su sami wani tasiri akan cin abinci ba kuma sun tabbatar da cewa OEA baya aiki a cikin kwakwalwa, amma a maimakon haka, yana haifar da sigina daban wanda ke shafar yunwa da halayen cin abinci.

Oleylethanolamide VS cannabinoid anandamide

An fara nazarin tasirin OEA saboda yana da alaƙa da wani sinadari, cannabinoid da aka sani da anandamide.Cannabinoids suna da alaƙa da shuka Cannabis, kuma anandamides da ke cikin shuka (da marijuana) na iya haɓaka sha'awar ɗan adam ta hanyar jawo martanin ciyarwa.Dangane da Wikipedia, Oleoylethanolamide shine analog ɗin monounsaturated na anandamide endocannabinoid.Kodayake OEA yana da tsarin sinadarai wanda yayi kama da anandamide, tasirinsa akan cin abinci da sarrafa nauyi ya bambanta.Ba kamar anandamide ba, OEA yana aiki ba tare da hanyar cannabinoid ba, yana daidaita ayyukan PPAR-α don tada lipolysis.

Tsarin ethanolamide mai-acid iri-iri: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) da anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd shine kawai masana'anta na kayan albarkatun kasa na OEA, PEA da AEA a China, idan kuna buƙatar samfurin da ƙimar farashin, da fatan za a jefar da mu imel a cikin shafin tuntuɓar mu.)

OEA yana ɗaure tare da babban kusanci ga mai karɓar mai karɓar mai haɓaka-proliferator-a (PPAR-a), mai karɓar makaman nukiliya wanda ke daidaita abubuwa da yawa na metabolism na lipid.

Tushen halitta na oleoylethanolamide

Oleoylethanolamide shine metabolite na halitta na oleic acid.Don haka, abinci mai ɗauke da oleic acid shine tushen OEA kai tsaye.

Oleic acid shine kitse na farko a cikin kayan lambu kamar zaitun, canola da sunflower.Hakanan ana iya samun Oleic acid a cikin man goro, nama, kaji, cuku, da sauransu.

Abubuwan abinci masu wadata a cikin oleic acid sun haɗa da: Canola Oil, Man Zaitun, Man Avocado, Almond Oil, Avocados, Babban Oleic Safflower Oil

Wasu bayanai game da Oleic Acid:

Daya daga cikin mafi yawan kitse a cikin nonon mutum

Yana samar da kashi 25% na mai a cikin madarar shanu

Monunsaturated

Omega-9 fatty acid

Tsarin sinadaran shine C18H34O2(CAS 112-80-1)

Ya bambanta da triglycerides

Ana amfani dashi a cikin kayan kwalliya masu tsada a matsayin mai tasiri sosai

Ana samunsa a cikin kitsen madara, cuku, man zaitun, man inabi, goro, avocado, qwai da nama

Maiyuwa ne ke da alhakin yawancin fa'idodin kiwon lafiya na man zaitun!

Yana samar da rukunin super gwarzo tare da sauran sunadaran madara don yaƙar ƙwayoyin cutar kansa

Amfanin Oleoylethanolamide

Oleoylethanolamide (OEA) yana da kyau a rasa nauyi a matsayin mai sarrafa abinci kuma yana tallafawa matakan cholesterol lafiya a cikin manya.

OEA a matsayin mai hana ci

Ciwon kai shine babban wurin sarrafa kuzari (abinci), sarrafa ci yana da mahimmanci wajen sarrafa nauyin jiki mai lafiya.Ta yaya OEA ke sarrafa sha'awar ku?Kuna iya bincika tsarin ayyuka a ƙasa.

OEA da cholesterol

Man zaitun babban tauraro ne na abinci mai gina jiki, kuma yana taimakawa rage “mummunan” LDL cholesterol kuma yana ƙara “mai kyau” HDL.Me yasa?Har zuwa 85% na man zaitun shine oleic acid, kuma babban lafiyayyen metabolite na oleic acid shine OEA (Oleoylethanolamide shine cikakken suna).Saboda haka, babu shakka cewa OEA yana taimakawa cholesterol lafiya.

Wasu sake binciken sun nuna cewa oleoylethanolamide yana da tasiri mai kyau akan damuwa, kuma ana buƙatar ƙarin hanyoyi da shaida don tallafawa.

Tsarin kera na Oleoylethanolamide

Matsakaicin kwararar Oleoylethanolamide yana ƙasa:

Matakan gaba ɗaya shine: reactiong→Tsarin tsarkakewa → Tacewa → Sake Narkar da shi a cikin ethanol →hydrogenation → Tace Liquid → Crystallization → Tacewa → Gwaji → Shiryawa → Karshen samfur

Hanyar aikin oleoylethanolamide

Don sanya shi a sauƙaƙe, oleoylethanolamide yana aiki azaman mai sarrafa yunwa.OEA tana iya sarrafa abincin ku ta hanyar gaya wa kwakwalwa cewa jiki ya cika, kuma ba a buƙatar ƙarin abinci.Kuna rage cin abinci kowace rana, kuma jikinku bazai yi kiba ba nan da nan.

Ayyukan anti-kiba na oleoylethanolamide (OEA) suna kamar yadda aka nuna a hoton.OEA an haɗa shi kuma an tattara shi a cikin ƙaramin hanji mai kusanci daga acid oleic da aka samu a abinci, kamar mai zaitun.Abincin mai-mai yawa na iya hana samar da OEA a cikin hanji.OEA yana rage cin abinci ta kunna homeostatic oxytocin da histamine da'ira da kuma hanyoyin hedonic dopamine.Akwai shaidar cewa OEA na iya rage siginar hedonic cannabinoid mai karɓa na 1 (CB1R), kunnawar wanda ke da alaƙa da haɓakar abinci.OEA yana rage jigilar lipid zuwa adipocytes don rage yawan kitse.Ƙarin bayani game da tasirin OEA akan ci abinci da metabolism na lipid zai taimaka wajen ƙayyade hanyoyin ilimin lissafin jiki waɗanda za a iya niyya don haɓaka ingantaccen hanyoyin kwantar da kiba.

OEA tana aiki don kunna wani abu da ake kira PPAR kuma a lokaci guda yana haɓaka mai-ƙonawa kuma yana rage ajiyar mai.Lokacin da kuke cin abinci, matakan OEA suna ƙaruwa kuma sha'awar ku tana raguwa lokacin da jijiyoyi masu alaƙa da kwakwalwar ku suka gaya masa cewa kun cika.PPAR-a rukuni ne na mai karɓar makamashin nukiliya wanda ke kunna ligand wanda ke da hannu a cikin maganganun kwayoyin halitta na lipid metabolism da makamashi homeostasis hanyoyi.

OEA yana nuna duk ma'anar ma'anar ma'anar satiety:

(1) Yana hana ciyarwa ta hanyar tsawaita tazara zuwa abinci na gaba;

(2) Ana daidaita tsarin sa ta hanyar samun abinci mai gina jiki da

(3) Matakan sa suna jujjuyawar circadian.

Oleoylethanolamide illa

Amincin Oleoylethanolamide babban damuwa ne tsakanin samfuran kari waɗanda ke son gwada wannan sinadaren labari a cikin dabarun asarar nauyi.

Bayan cikakken nazari na duk wallafe-wallafe da bayanai, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta da wata damuwa game da amincin OEA.RiduZone shine farkon alama na oleoylethanolamide foda tun daga 2015.

Oleoylethanolamide metabolite ne na oleic acid, wanda wani bangare ne na ingantaccen abinci na yau da kullun.Yana da lafiya a gwada kari na OEA, kuma ba a sami rahoton wani mummunan tasiri ba.

an ba da rahoton sakamako.

Oleoylethanolamide Gwajin ɗan adam

A cikin binciken daya, hamsin (n = 50) batutuwa na ɗan adam da ke sha'awar rasa nauyi an shawarci su ɗauki OEA 2-3 sau / rana, mintuna 15-30 kafin cin abinci na makonni 4-12.Abubuwan da suka shafi sun haɗa da waɗanda ba su yi amfani da samfuran asarar nauyi ba a baya, waɗanda suka sami abubuwan da ba su da kyau tare da sauran samfuran asarar nauyi, waɗanda asarar nauyi ta mamaye wasu ma'aunin asarar nauyi kamar phentermine, waɗanda ke ƙoƙarin aiwatar da canje-canjen salon rayuwa (sarrafa sarrafawa da motsa jiki na yau da kullun). ), da kuma waɗanda ake kulawa da su don yanayin kiwon lafiya ciki har da rashin haƙuri na glucose, dyslipidemia, hauhawar jini da cututtukan zuciya.

A cikin binciken na biyu, an umurce batutuwan 4 tare da ma'auni na asali na 229, 242, 375 da 193 lbs bi da bi, don ɗaukar capsules Oleoylethanolamide (capsule ɗaya mai ɗauke da 200mg 90% OEA).Abubuwan da ake amfani da su sun ɗauki capsules 4 (1 capsule 15-30 mintuna kafin abinci kuma za su ɗauki ƙarin capsule kafin cin abinci mafi girma na rana) kowace rana na kwanaki 28.Maudu'in karshe an riga an yi shi da jeri bandeji na cinya.An umurci batutuwa da kada su yi canje-canje ga abincinsu da halayen motsa jiki.

Sakamako

A cikin binciken farko, batutuwa sun rasa matsakaicin 1-2 lbs / mako.Babu illa sai dai majiyyaci guda daya da ke fama da tashin hankali na wucin gadi wanda aka warware cikin kasa da mako guda.A cikin binciken na biyu, 3 daga cikin batutuwa 4 sun ba da rahoton asarar nauyi (3, 7, 15 da 0 lbs bi da bi).Duk batutuwa 4 sun ba da rahoton raguwar 10-15% a girman yanki, tsawan lokaci tsakanin abinci, kuma babu illa.

Idan kuna sha'awar ƙarin wallafe-wallafen gwajin ɗan adam tare da OEA, da fatan za a ziyarci hanyoyin haɗin PDF masu saukewa.

Oleoylethanolamide sashi

Akwai ƙayyadaddun bayanan bincike akan ƙarin OEA na yanzu a cikin mutane, kuma yayin da ake ɗauka a matsayin mai aminci, babu wani adadin da aka ba da shawarar.Koyaya, akwai wasu kari akan kasuwa, kuma kuna iya samun wasu don bayanin ku.

Dosing ɗin kowace rana na RiduZone (mai suna OEA/Oleoylethanolamide 90%) shine 200mg (1 capsule tare da OEA kawai a ciki).Idan aka haɗe tare da sauran kayan aikin asarar nauyi, adadin yau da kullun ya zama ƙasa da ƙasa, a ce 100mg ko 150mg.Wasu kari

Ana ba da shawarar shan kayan abinci na oleoylethanolamide minti 30 kafin karin kumallo da abincin dare, za ku ji daɗi yayin cin abinci kuma sakamakon haka zai iya rage cin abinci.

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