Oleanolic acid foda

Oleanolic acid wanda shine triterpenoids pentacyclic guda uku wanda aka ware daga tsire-tsire na Gentianaceae na Swertia mileensis dukan ciyawa ko 'ya'yan itace masu mahimmanci, tare da jiki kyauta da glycosides a yawancin tsire-tsire.Oleanolic acid yana da fadi da kewayon tsire-tsire, kuma matsakaicin abun ciki shine 0.2% - 2%.Babban abun ciki na Cucurbitaceae shine 1.5% ~ hunchback kasa 2%, abun ciki na 'ya'yan itace na 0.6% ~ 0.7%.Oleanolic acid wani nau'in fili ne na pentacyclic triterpenoid wanda aka ware daga 'ya'yan itacen Asteraceae, Syzygium sylvestris, ko Ligustrum lucidum.Adjuvant cuta ce ta hanta kuma ana amfani dashi a asibiti don kamuwa da cuta.Mugun jaundice hepatitis yana da bayyanannen tasiri akan rage alanine aminotransferase da yellowing.Oolic acid ne pentacyclic triterpenoids ware daga 'ya'yan itace na swertia chinensis ko fructus ligustris daga gentianaceae shuka.Ana samun Oleanolic acid a cikin tsire-tsire, tare da babban abun ciki na 0.2% ~ 2% [1].Abubuwan da ke cikin ƙasa na calabash shine 1.5% ~ 2%, kuma abun ciki na 'ya'yan itacen fructus ligstris shine 0.6% ~ 0.7%.Oleanolic acid shine farin crystal acicular (ethanol), mara wari kuma mara daɗi.Rashin kwanciyar hankali ga acid da tushe.Narke batu na 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, insoluble a cikin ruwa, mai narkewa a cikin methanol, ethanol, ethyl ether, acetone da chloroform. a cikin abinci da tsire-tsire na magani, wanda ke da alaƙa da acid betulinic Ana iya samunsa a cikin Phytolacca americana (Pokeweed na Amurka), da Syzygium spp, tafarnuwa, da sauransu.
An samo Oleanolic acid don nuna aikin anti-HIV mai karfi, an yi amfani da sinadarin betulinic acid da ke da alaƙa don ƙirƙirar magani na balagagge na kasuwanci na farko.An fara nazarinsa kuma an ware shi daga tsire-tsire da yawa, ciki har da Rosa woodsii (ganye), Prosopis glandulosa (ganye da twigs), Phordendron juniperinum (dukan shuka), Syzygium claviflorum (ganye), Hyptis capitata (dukan shuka), da Ternstromia gymnanthera (aerial). part).Sauran nau'in Syzygium ciki har da apple apple (Syzygium samarangense) da furen apple sun ƙunshi shi.

Sunan samfur: Oleanolic Acid98%

Musammantawa: 98% ta HPLC

Tushen Botanic: Olea Europea Extract

Sunan sinadarai: (3β) -3-Hydroxyolean-12-en-28-oic acid

CAS No:508-02-1

Sashin Amfani: Leaf

Launi: Farin foda mai ƙamshi da dandano

Matsayin GMO: GMO Kyauta

Shiryawa: a cikin 25kgs fiber ganguna

Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi

Rayuwar Shelf: watanni 24 daga ranar samarwa

Meneneoleanolic acid?

Oleanolic acid (OA), na halitta hydroxyl pentacyclic triterpenoid acid (HPTA) kama da betulinic acid, ursolic acid;yana da fa'idodi kamar su antibacterial, anti-inflammatory, antitumor ayyuka.

A ina za ku samuoleanolic acid?

Oleanolic acid ya yi amfani da al'ada don maganin cututtuka daban-daban, zaka iya samun shi a cikin abinci da tsire-tsire.

Wasu 'ya'yan itatuwa kamar apples, rumman, lemun tsami, bilberries, zaituni sun ƙunshi oleanolic acid ma.

A halin yanzu, Sin ganyeHemsley Chinensis Cognhar yanzu shine mafi kyawun kayan kasuwanci don hako oleanolic acid.

Hemsley Chinensis Cogn.Gabatarwa

Hemsleya chinensis Cogn.ganyen hawan dutse ne na shekara-shekara, kuma shi ne maganin gargajiya na kasar Sin.

Iyali: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Nau'i: H. amabilis

Ana rarraba ganyen a lardunan Guangxi, da Sichuan, da Guizhou, da Yunnan, da Hubei, da dai sauransu. An haife su a gefen dazuka da ciyayi na kwari a tsayin da ya kai kimanin mita 2,000.

Abubuwan da ke aiki: ya ƙunshi Hemslolide Mal, Ma3, H1;Chikusetsusaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacin Ⅱb-2-beta-D-glucopyranoside.

Darajar Magani:

Hemsleya chinensis Cogn.shi ne yafi na detoxification, sterilization, anti-mai kumburi, ƙarfafa ciki da kuma rage zafi.A halin yanzu, akwai tsantsa foda, ko shirye-shirye na fili irin su capsules, allunan, kwayoyin gastrointestinal, da dai sauransu, waɗanda ake amfani dasu sosai a aikin asibiti.

Cire Oleanolic acid dagaHemsleya Chinensis Cogn.

Formulas dauke da Oleanolic acid a cikin kari na Abinci

Mun gano cewa oleanolic acid da ake amfani da shi a cikin kayan abinci na kiwon lafiya ya fito ne daga nau'ikan nau'ikan tsire-tsire guda uku: cirewar ganyen Loquat, tsantsar Hemsley Chinensis, da tsantsar Basil mai tsarki.

• Basil foda (leaf) (0.4% Ursolic acid da Oleanolic acid, 2.0 MG)
• Holy Basil supercritical CO2 cire (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid da Oleanolic acid, 1.5 MG)
• Loquat Extract ('ya'yan itace) (samar da Ursolic acid, Oleanolic Acid) (daidaitacce zuwa Ursolic acid ga Bauta 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) da ursolic acid (UA) triterpenoids ne na halitta waɗanda ke da tsarin sinadarai iri ɗaya.

Wadannan mahadi na triterpenoids an san su wanzu a cikin ganyayyaki na magani da abinci.

Suna da kaddarorin magunguna na yau da kullun: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, aikin anti-HIV, antioxidant, da ayyukan rigakafin haihuwa.

Bambancin OA da UA:

Ayyukan Halittu na Oleanolic Acid

1. Maganin Tumour/Anti-Cancer Effects

Tasirin hanawa na oleanolic acid akan ciwon daji na hepatocellular ta hanyar kama ERK-p53-matsakaici na sake zagayowar cell da apoptosis mai dogaro da mitochondrial.

- na Xin Wang, Hua Bai, da dai sauransu Masu bincike

OA ya nuna tasirin hanawa akan HCC ta hanyar shigar da apoptosis da kama sake zagayowar tantanin halitta duka a cikin ciwace-ciwacen da aka dasa da kuma a cikin ƙwayoyin HepG2.

OA ta haifar da apoptosis ta hanyar mitochondrial, shaida ta hanyar hana Akt/mammalian manufa na hanyar rapamycin.

OA ya haifar da kama G2/M tantanin halitta ta hanyar p21-sakanci-ƙasa-tsari na cyclin B1/cdc2.

OA ya nuna mahimman ayyukan antitumor a cikin HCC a cikin vivo da samfuran in vitro.Waɗannan bayanan suna ba da sabon haske game da hanyoyin da ke ƙarƙashin tasirin antitumor na OA.

Bugu da ƙari, bincike ya nuna cewa OA da tushensa Oleanolic acid methyl ester suma suna da tasiri akan kansar nono, kansar huhu, kansar mafitsara, kansar mahaifa, ƙwayoyin kansa na pancreatic…

2. Ayyukan Antimicrobial

Ana sa ran OA ta mallaki aikin rigakafin ƙwayoyin cuta a kan ɗimbin ƙwayoyin cuta domin tana taka muhimmiyar rawa wajen kare ƙwayoyin cuta a cikin tsirrai.

OA ya nuna matsakaicin aiki akan Staphylococcus aureus da Bacillus Thuringiensis a 62.5 µg/mL da Escherichia coli, Salmonella Enterica, da Shigella dysenteriae a 31.2 μg/mL mafi ƙarancin inhibitory taro (MIC).

3. Ability na Hepatoprotective

Ɗayan sanannen abubuwan da ke tattare da rayuwa na OA shine kariyar hanta daga guba kuma a halin yanzu ana amfani da shi azaman maganin maganin hanta a China.

A cikin berayen Wistar albino, OA daga Flavera Trinervia an yi amfani da shi kuma yana da babban tasiri na kariya akan gubar hanta da ke haifar da ethanol ta hanyar maido da matakan enzyme hepatotoxic serum marker.Wannan binciken ya ba da shawarar ikon antioxidant na OA a matsayin wata hanyar da za ta yuwu ta iya kare hanta.

Oleanolic acid da abubuwan da suka samo asali

Gwajin Clinical Oleanolic Acid

Oleanolic acid (wanda aka samo daga zaitun), akwai kimanin gwaje-gwaje na asibiti 500 da aka yi rajista, ya nuna yana da tasiri mai amfani a cikin gwaje-gwaje na asibiti akan cututtukan koda na kullum, ciwon sukari mellitus nau'in 2, da wasu yanayi masu kumburi irin su arthritis.

Mafi shahararrun abubuwan da aka samo a cikin gwaji na asibiti sune bardoxolone methyl (CDDO-Me).An ƙididdige CDDO-Me a cikin biopsies na ƙari, kuma yana iya taka rawa wajen magance cututtukan koda na yau da kullun, a halin yanzu ana tantance shi a cikin tasirin hauhawar jini.

Matsayin Pharmacopoeia na China na Oleanolic Acid

Oleanolic acid yana ba da shawarar sashi

Bisa ga ma'aunin Pharmacopoeia na kasar Sin, kashi na Oleanolic acid shine 20 ~ 80mg a kowane lokaci, 60 ~ 240mg kowace rana.

Oleanolic acid illa

Oleanolic acid da aka yi amfani da shi azaman maganin hanta (OTC) tsawon shekaru a China.

Idan fiye da kima ko kuskure, ƙananan marasa lafiya suna da bushe baki, gudawa, rashin jin daɗi na ciki na sama, kuma suna iya ɓacewa bayan maganin bayyanar cututtuka.

Da fatan za a tuntuɓi likitan ku ko likitan magunguna kafin amfani da wannan samfurin.

Aiki:

1.Oleanolic acid ne in mun gwada da ba mai guba, antitumor, kuma hepatoprotective, kazalika da exhibiting antiviral Properties.
2.Oleanolic acid da aka samu don nuna karfi anti-HIV aiki.
3.Oleanolic acid shine babban mai kare kwayoyin halitta daga damuwa na oxidative da electrophile.
4.Oleanolic acid yana da babban tasiri a kan trating cutar hanta, m icteric hepatitis da na kullum hepatitis.
Aikace-aikace:
1. Aiwatar da shi a filin abinci, yana iya aiki azaman albarkatun shayi don rage phlegm;
2. An yi amfani da shi a filin magani, ya zama sabon maganin ciwon daji tare da ƙananan mai guba;
3. Ana amfani da shi a filin kwaskwarima, yana iya ƙarfafa zagawar jini da kuma cire abin sha.