Beta-nicotinamide Mononucleotide (NMN), samfurin amsawar NAMPT da maɓallin NAD + matsakaici, yana haɓaka rashin haƙuri ta glucose ta hanyar maido da matakan NAD + a cikin berayen T2D na HFD.NMN kuma yana haɓaka hanta insulin hanta kuma yana maido da maganganun kwayoyin halitta da ke da alaƙa da damuwa na oxidative, amsawar kumburi, da rhythm na circadian, wani ɓangare ta hanyar kunna SIRT1.Ana amfani da NMN don nazarin abubuwan ɗaurewa a cikin RNA aptamers da hanyoyin kunna ribozyme da suka haɗa da β-nicotinamide mononucleotide (Beta-NMN) -abubuwan RNA da aka kunna.
Nicotinamide mononucleotide ("NMN" da "β-NMN") wani nucleotide ne wanda aka samo daga ribose da nicotinamide.Niacinamide (nicotinamide,) wani nau'i ne na bitamin B3 (niacin.) A matsayin maƙasudin sinadarai na NAD+, yana iya zama da amfani a rigakafin pellagra.
Sigar da ba ta da hankali, niacin, ana samun ta a cikin nau'o'in abinci masu gina jiki: Gyada, Naman kaza (portobello, gasashe), Avocado, Green Peas (sabo), da wasu kifi da naman dabbobi.
A cikin nazarin [a kan mice], NMN ya nuna don sake juyar da rashin aikin jijiya mai alaka da shekaru ta hanyar rage yawan damuwa.
Suna: Beta-Nicotinamide Mononucleotide
Saukewa: 1094-61-7
Sunan samfurin: Beta-Nicotinamide Mononucleotide;NMN
Sauran suna: β-D-NMN; BETA-NMN; beta-D-NMN; NMN zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide; Nicotimide mononucleotide; Nicotinamide mononuclotide
Saukewa: 1094-61-7
Tsarin kwayoyin halitta: C11H15N2O8P
Nauyin Kwayoyin: 334.22
Tsafta: 98%
Adana Zazzabi: 2-8°C
Bayyanar: Farin foda
Amfani: anti-tsufa
Aiki:
1.Nicotinamide mononucleotide a cikin kwayoyin jikin mutum suna taka muhimmiyar rawa wajen samar da makamashi, yana shiga cikin NAD intracellular (nicotinamide adenine dinucleotide, canjin makamashin kwayar halitta mai mahimmanci coenzyme) kira, wanda aka yi amfani da shi a cikin maganin tsufa, faduwar jini sugar da sauran kayan kiwon lafiya.
2. Nicotinamide Mononucleotide shine bitamin mai narkewa da ruwa, Samfurin shine farin crystalline foda, wari ko kusan mara wari, ɗanɗano mai ɗaci, mai narkewa cikin ruwa ko ethanol, mai narkewa a cikin glycerin.
3.Nicotinamide Mononucleotide yana da sauƙin sha na baka, kuma ana iya rarraba shi a cikin jiki, abubuwan da suka wuce gona da iri ko samfuri suna fitar da sauri daga fitsari.Nicotinamide wani bangare ne na coenzyme I da coenzyme II, yana taka rawar isar da hydrogen a cikin sarkar iskar oxygen ta halitta, na iya haɓaka hanyoyin iskar oxygenation na ƙwayoyin cuta da ƙwayoyin nama, kula da nama na al'ada (musamman fata, fili mai narkewa da tsarin juyayi) mutunci yana da muhimmiyar rawa. .
Bugu da ƙari, nicotinamide yana da rigakafi da kuma kula da toshewar zuciya, aikin kumburin sinus da arrhythmias na gwaji mai sauri, nicotinamide na iya inganta haɓakar bugun zuciya da toshewar atrioventricular ta hanyar verapamil.
