Sunan samfur:Nicotinamide riboside chloride foda
Wani suna: 3- (Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride (1: 1); Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, bitamin NR; Niagen, TRU NIAGEN
CASNO: 23111-00-4
Tsarin kwayoyin halitta: C11H15N2O5.Cl
Nauyin Kwayoyin: 90.70 g/mol
Tsafta: 98%
Matsayin narkewa: 115 ℃-125 ℃
Bayyanar: Kashe Fari zuwa Kodadden Fada mai Rawaya
Amfani: Yana haɓaka matakan NAD+, Yana goyan bayan tsufa lafiya da ƙwaƙwalwa/fahimi
Aikace-aikace: azaman kari na abinci, abinci mai aiki, da abubuwan sha
Shawarar sashi: ba fiye da 180 MG / rana ba
Nicotinamide riboside sabon nau'i ne na Vitamin B3 wanda aka yaba, tare da kaddarorin na musamman;shi ne ainihin maƙasudin NAD +.
Nicotinamide riboside (NR), wanda aka fara bayyana shi a cikin 1944 a matsayin haɓakar haɓaka (Factor V) don mura Haemophilus, kuma a cikin 1951, NR, an fara bincikar shi azaman rabo na rayuwa a cikin kyallen jikin dabbobi masu shayarwa.
Kamar yadda zaku iya lura cewa, akwai nau'ikan NR guda biyu, ɗayan shine Nicotinamide Riboside, ɗayan kuma shine Nicotinamide Riboside chloride.
Maganar sinadarai, su biyu ne gaba ɗaya mabanbanta mahadi tunda suna da lambobin CAS daban-daban, NR tare da 1341-23-7 yayin da NR chloride tare da 23111-00-4.NR ba ta da ƙarfi a zafin daki, yayin da NR chloride yana da ƙarfi.Shahararriyar Alamar Haƙƙin mallaka mai suna NIAGEN®, wanda Chromadex Inc ya saki a cikin 2013, shine nau'in Nicotinamide riboside chloride, yana nufin juyar da alamun tsufa daga cikin jikin ku.Nicotinamide Riboside da aka ƙera daga Cima Science shima yana cikin foda na chloride.Idan ba a bayyana ba, NR za ta koma zuwa NR chloride form a cikin labarin da ke ƙasa.
Nicotinamide riboside tushen abinci
Adadin NR a cikin abinci shine minti daya, idan aka kwatanta da wancan a cikin abubuwan abinci mai gina jiki.Koyaya, menene tushen abinci na farko waɗanda ke ɗauke da nicotinamide riboside (NR)?
Nonon saniya
Nonon saniya yawanci yana da ~ 12 μmol NAD (+) precursor bitamin/L, wanda 60% ya kasance a matsayin nicotinamide, kuma 40% yana halin yanzu kamar NR.(Madara ta al'ada ta ƙunshi fiye da NR fiye da madarar halitta), binciken da Jami'ar Iowa ta buga, a cikin 2016
Yisti
Wani tsohon binciken ya ce, "Wani abu mai hanawa ya keɓe daga yisti kuma an gano shi shine nicotinamide riboside, yana iya kasancewa daga NAD (P) yayin shirye-shiryen abubuwan yisti, ko kuma daga abubuwan yisti na abinci yayin narkewa a cikin vivo."Duk da yake babu ƙididdiga bayanai akan yisti
Giya
Giya yana da adadin adadin kuzari kuma shan waɗanda ke cikin nau'in ruwa kamar wannan zai sami tasirin glycemic;takardun bincike daban-daban sun ambaci giya a matsayin tushen abinci na nicotinamide riboside.
Hakanan, ana iya samun adadin NR kamar furotin whey, namomin kaza, da sauransu.
Ga mutane da yawa, kiwo ba su da iyaka don wasu dalilai.Tushen abinci na nicotinamide riboside na iya zama da amfani, amma ba su da inganci fiye da kari na NR.
Me yasa Nicotinamide Riboside (NR) ya ayyana azaman ingantaccen NAD + precursor bitamin invertebrates?
Akwai hanyoyi guda biyar na tunani da ke goyan bayansa:
Murar Haemophilus, kwayar cutar mura, wacce ba ta da hanyar de novo kuma ba za ta iya amfani da Na ko Nam ba, ta dogara sosai kan NR, NMN, ko NAD+ don haɓaka cikin magudanar jini.
Madara shine tushen NR.
NR yana kare murine DRG neurons a cikin ex vivo axonopathy assay ta hanyar shigar da rubutun nicotinamide riboside kinase (NRK) 2 gene.
Ƙarar NR da abubuwan haɓakawa suna haɓaka tarin NAD + a cikin yanayin dogaro da kashi a cikin layin salula na ɗan adam.
Candida glabrata, naman gwari mai dacewa wanda ya dogara da NAD + precursor bitamin don girma, yana amfani da NR yayin kamuwa da cuta.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (ko nicotinic acid), wani nau'i ne na kwayoyin halitta da kuma nau'i na bitamin B3, muhimmin kayan gina jiki na ɗan adam.Yana da dabara C6H5NO2.
Nicotinamide ko kuma ake kira niacinamide wani nau'i ne na bitamin B3 da ake samu a abinci kuma ana amfani dashi azaman kari na abinci da magani.Yana da dabara C6H6N2O.
Nicotinamide riboside wani nau'i ne na pyridine-nucleoside na bitamin B3 wanda ke aiki azaman mafari ga nicotinamide adenine dinucleotide ko NAD +.Yana da dabara C11H15N2O5+.
Amfanin Lafiya na Nicotinamide Riboside
Nicotinamide Riboside yana taimakawa samar da makamashi
A cikin dabbobi, NR kari ya rage yawan amfani da NAD, wanda ya inganta aikin mitochondrial, da sauri dawo da ƙwayar tsoka, da kuma kiyaye ƙarfin NAD matakan da ƙarfin motsa jiki a cikin tsofaffin mice, yana taimakawa wajen kula da ƙwayar tsoka da aiki, yana goyon bayan samar da makamashi.
Nicotinamide Riboside yana inganta aikin fahimi
NR yana adana ƙwayoyin jijiyoyi a cikin kwakwalwa ta hanyar kunna SIRT3, Ƙarfafawa yana ƙarfafa hanyoyin NAD kuma yana taimakawa hana lalacewa a hankali.
NR ya haɓaka aikin fahimi da rage jinkirin ci gaban cutar Alzheimer a cikin berayen da aka ba NR tsawon watanni uku.
Nicotinamide Riboside yana hana asarar ji
Ta hanyar kunna hanyar SIRT3, binciken UNC ya gano yana taimakawa kare rodents daga asarar ji da hayaniya ke jawo.
Nicotinamide Riboside yana kare hanta
Ɗaukar NR da baki yana ƙara NAD a cikin jiki, wanda ke taimakawa wajen kare hanta.NR ta dakatar da tarin kitse, saukar da damuwa na iskar oxygen, hana kumburi, da haɓaka haɓakar insulin a cikin hantar mice.
Bugu da ƙari kuma, NR zai iya tsawaita tsawon rai, Ƙara yawan ƙwayar cuta, yana tallafawa yaki da ciwon daji, rage alamun ciwon sukari, yana ƙaruwa metabolism, zai iya taimakawa tare da asarar nauyi.
Shin Nicotinamide Riboside lafiya ne?
Ee, NR yana da lafiya.
NR tana da gwaje-gwajen asibiti guda uku da aka buga waɗanda ke tabbatar da lafiyar ɗan adam.
Bincika a hankali da kuma jaddada duk cikakkun bayanai na asibiti da na asibiti da ke kan NR sun tabbatar da cewa yana da aminci kuma an jure shi sosai.
Niagen yana da aminci kuma GRAS, ta amfani da hanyoyin kimiyya, ƙarƙashin Dokar Abinci, Magunguna, da Kayan kwalliya ta Tarayya (FFDCA).
Gwajin Dan Adam na Nicotinamide Riboside
Akwai da yawa pre-clinical karatu da aka gudanar gwajin NR a daban-daban tsarin model.
A cikin 2015, an kammala karatun likitancin ɗan adam na farko, kuma sakamakon ya nuna cewa NR cikin aminci da haɓaka matakan NAD a cikin masu sa kai na ɗan adam lafiya.
Gwajin gwaji na asibiti da ke sarrafa placebo na nicotinamide riboside a cikin maza masu kiba ta hanyar bazuwar: aminci, insulin-hankali, da tasirin motsa jiki.
–An buga shi a cikin Jarida ta Amurka/Jarida na Abinci na Clinical
Sakamako: 12 wk na kari na NR a cikin allurai na 2000 mg/d ya bayyana lafiya, amma baya inganta haɓakar insulin da glucose metabolism na jiki gaba ɗaya a cikin kiba, maza masu jure insulin.
Abubuwan kari na nicotinamide na riboside na yau da kullun ana jurewa sosai kuma yana haɓaka NAD + a cikin koshin lafiya masu matsakaici da tsofaffi.
–An buga a cikin Sadarwar yanayi
Nicotinamide Riboside Musamman da Baki Bioavailable a cikin Mice da Mutane
–An buga a cikin Sadarwar yanayi
Anan mun ayyana lokaci da tasirin dogaro da kashi na NR akan metabolism na NAD na jini a cikin mutane.Rahoton ya nuna cewa NAD na jinin ɗan adam na iya tashi kamar ninki 2.7 tare da kashi ɗaya na baki na NR a cikin binciken matukin jirgi na mutum ɗaya kuma NR na baka yana haɓaka NAD na hanta na linzamin kwamfuta tare da bayyananniyar magunguna.
