Nicotinamide mononucleotide babban foda
Sunan samfur:Nicotinamide mononucleotide foda
Makamantu: NMNβ-Nicotinamide Mononucleotide, Beta-Nicotinamide Mononucleotide
Lambar CAS: 1094-61-7
Ƙayyadaddun bayanai: 99% min
Tsarin kwayoyin halitta: C11H15N2O8P
Nauyin Kwayoyin Halitta: 334.221 g/mol
Kunshin: 1kg/bag, 25kg/drum
Menene Nicotinamide Mononucleotide?
Nicotinamide mononucleotide, wanda aka rage a matsayin NMN, yana da sunaye masu zuwa:
β-NMN, BETA-Nicotinamide Mononucleotide;
BETA-NMN;BETA-NICOTINAMIDE MONOUCLEOTIDE;
BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;
NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5′-PHOSPHATE;NICOTINAMIDE RIBOTIDE;
Abubuwan da aka bayar na NICOTINAMIDE MONOUCLEOTIDE
NMN yana wanzuwa a cikin halittu daban-daban ciki har da mutane kuma wani fili ne mai mahimmanci don kiyaye ayyukan jiki.Ana sake amfani da NMN bayan da jiki ya daidaita shi, kuma bitamin B3 a cikin abinci yana iya haɗa NMN.
Kafin mu fahimci nicotinamide mononucleotide, muna buƙatar sanin menene.Nicotinamide mononucleotide (NMN) shine muhimmin mafari na NAD+, kuma NAD + hanya ce mai mahimmanci ta gyaran tantanin halitta a cikin mutane.Lokacin da ’yan Adam suke cikin jarirai da yara ƙanana, girma da haɓakarsu suna da sauri sosai, kuma da haɓakar shekaru, aikin jikin ɗan adam zai ragu a hankali.Misali mai sauki kamar tsohon;bazata makantar makanta ba.An ragargaza ƙullun, kuma mafi muni, sun sami munanan raunuka.A cikin aiwatar da tsufa na sel ɗan adam, adadin NAD + zai ragu sosai idan aka kwatanta da baya saboda metabolism da jiki kanta.
Nicotinamide mononucleotide wani muhimmin bangare ne na farfadowar dan Adam.Masana kimiyya a duniya sun gano cewa nicotinamide mononucleotide yana da wani tasiri akan tsufa.A cikin zurfin bincike, mabuɗin nicotinamide mononucleotide shine cewa shine mafarin NAD +, wanda zai canza don NAD +, yana haɓaka abubuwan gyara tantanin halitta a cikin ƙwayoyin ɗan adam, tsayayya da tsarin tsufa, kuma suna da damar sake farawa aikin haɓakawa tantanin halitta, wanda shine aikin haɓaka rayuwa na nicotinamide mononucleotide.
Nicotinamide mononucleotide a zahiri yana wanzuwa a cikin kowane tantanin halitta na jikinmu kuma muhimmin sashi ne na gyaran jikin mutum.Yana da metabolite don kiyaye NAD + biosynthesis na al'ada, kuma wannan abu na iya daidaita ilimin lissafin jiki yayin kewayawar jiki, kuma a cikin takamaiman cututtukan cututtukan fata.Yana taka muhimmiyar rawa a aikin tantanin halitta.
Ƙarin da ke ɗauke da NMN
Akwai samfuran ƙarin NMN da yawa akan siyarwa yanzu.Wasu sun shahara tsakanin masu amfani da ƙarshen, kamar NMN Pure, Ultra NMN, da sauransu akan Amazon da sauran shagunan kan layi.
Wasu nau'ikan suna tare da NNN kawai a ciki, wasu kuma tare da wasu kayan aikin rigakafin tsufa, irin su resveratrol, pterostilbene, nuna tushen tushen, da sauransu.
Dukansu nau'ikan capsule da na kwamfutar hannu suna samuwa, a ƙasa akwai wasu ƙarin bayanan NMN daga wasu alamun NMN:
125mg alama shine sanannen sashi don yawancin abubuwan NMN, kodayake wasu suna rubuta 260mg a kowace capsule akan takalmomin su tare da girman girman 2 capsules ko allunan yau da kullun.Babu a hukumance da aka ba da shawarar sashi a halin yanzu.
Hanyar aikin nicotinamide mononucleotide
Nicotinamide mononucleotide an canza shi zuwa wani abu "nicotinamide adenine dinucleotide (NAD)" abu mai mahimmanci don metabolism na makamashi a cikin jiki.A cikin gwajin linzamin kwamfuta, an tabbatar da cewa nicotinamide mononucleotide na iya kunna kwayar halittar da ake kira acetylase a cikin jiki, ta yadda zai yi tasiri kamar tsawaita rayuwa da kuma magance ciwon sukari.NAD wani abu ne da jikin ɗan adam ke iya samarwa.Nazarin ya nuna cewa abun ciki na NAD a cikin jiki yana raguwa da shekaru.
Haɓaka kumburin da ke tattare da tsufa na iya lalata ƙarfin jiki don samar da NMN, wanda hakan ke haifar da raguwar NAD.
NMN wani abu ne na farko na mahimmancin coenzyme NAD + a cikin jiki.Nicotinamide mononucleotide muhimmiyar rawa ce a cikin samar da makamashin tantanin halitta, kuma yana da hannu cikin haɗakar NAD + na cikin salula (nicotinamide adenine dinucleotide, coenzyme don canjin makamashin tantanin halitta).
An gane NMN bisa hukuma a matsayin abu na farko na halitta a duniya wanda aka tabbatar ta hanyar tsauraran gwaje-gwajen kimiyya don jujjuya da jinkirta tsufa da tsawaita rayuwa.
A cikin 2017, binciken ya nuna cewa NMN na iya magance NR da NMN ataxia, kuma NR baya canza aikin SIRT3 ko inganta aikin zuciya.
NAD + wadata ba zai tsaya ba - za a ci gaba da cinye shi kuma a sake cika shi, kuma duka NAD + tafkin yana jujjuya sau 2-4 a rana.
Wannan sake zagayowar ta hanyar hanyoyin gyara ne, wanda enzyme Nampt ke haifar da NAM zuwa NMN sannan kuma ya daidaita zuwa NAD +.Nampt shine matakin iyakar saurin kamun kifi.
Nicotinamide Mononucleotide VS.Nicotinamide Riboside
A zamanin yau, duniya tana da wadata a cikin bincike daban-daban tare da NR, kuma gwajin jikin mutum ya sa sakamakon NR akan bayanan ka'idar ya fi NMN kyau.Duk da haka, binciken ya nuna cewa NR ya fara aiki a cikin jikin mutum kuma har yanzu yana buƙatar samun kwarewa na ɗan lokaci.Makullin shine duka NR da NMN sune magabatan NAD +, yayin da Nicotinamide Riboside (NR) shine farkon NMN da NAD +, don haka NR yana canzawa.Yana ɗaukar ɗan lokaci kafin NAD +.Idan aka kwatanta da tasirin NMN nan take, mintuna 15 na NR babban gibi ne.
Ana iya gani daga zanen zagayowar da ke sama cewa NAMPT muhimmin abu ne da ke iyakance haɓakar NMN.Yayin da shekaru ke ƙaruwa, ba jikin mutum ba ya so ya zama ƙarami, amma aikin enzyme na NAMPT yana raguwa lokacin da aka samar da makamashi da abubuwan gina jiki.Yayin da aka rage sake zagayowar NAM, an rage hajojin NAD+ ta dabi'a.
Ana iya canza NR zuwa NMN ko zuwa NAM, dangane da rawar Nrk1 enzyme don sanin wane nau'in ingancin NR iri ɗaya zai samar da ƙarin.Idan an canza shi zuwa NAM, ana kuma iyakance shi ta hanyar NAMPT enzyme.Idan aka kwatanta da aikin kai tsaye na NMN don samar da NAD +, tasirin daidaitaccen adadin NR yana raguwa da yawa.
Me yasa ba a dauki NAD+ ba?
Ba za a iya ɗaukar NAD+ kai tsaye zuwa cikin sel ta hanyar gudanar da baki ba saboda yawan nauyin kwayoyin sa.Ana samun ƙarin ƙarin NAD+ ne kawai ta hanyar shigar da ƙaramin nauyin NAD+ precursor.
Koyaya, ana iya yin NMN zuwa samfura iri-iri, waɗanda zasu iya zama capsules, allunan, ko ma granules saboda yanayin mai narkewa.Solubility na NMN a cikin ruwa shine 35mg/ml.
A wannan ma'anar, NMN ya fi NAD + kyau, kuma ya fi nicotinamide riboside kai tsaye.
Nicotinamide Mononucleotide fa'idodin
Babban illolin NMN sune kamar haka:
- anti-oxidation
- Saukake ɓacin rai
- Gyaran DNA
- Goyi bayan tasirin neuroprotective
- Inganta aikin zuciya da kare zuciya
- Inganta matsayin masu cutar Alzheimer
Babban fasalin NMN shine cewa yana iya juyar da tsufa da tsawaita rayuwa.
Nicotinamide Mononucleotide illa
Tun da yake NMN a halin yanzu yana gudanar da gwaje-gwajen dabba kawai, manyan gwaje-gwajen ɗan adam ba su fara ba tukuna, don haka illar da za a iya tantancewa har yanzu ba a sani ba.Duk da haka, bisa ga tsarin aikin NMN, ana iya gane cewa marasa lafiya na ciwon daji kada su dauki shi kamar yadda zai yiwu.Saboda canjin NMN yana haɓaka samar da NAD +, yayin da ƙwayoyin cutar kansa ke daidaitawa da ayyukan ilimin lissafi a hankali, haɓakar metabolism na iya haifar da yaduwar wasu ƙwayoyin cutar kansa.
Lokacin amfani da nicotinamide nucleoside kari kamar NMN, aikin motsa jiki na iya shafar.A cikin berayen, berayen da aka yi musu allura tare da abubuwan NAD+ sun nuna ƙarancin aiki fiye da rukunin kulawar su.
