Mitoquinone

Takaitaccen Bayani:

Mitoquinone (444890-40-9) antioxidant ne wanda aka yi niyya na mitochondrial. Nuna zuciya da tasirin neuroprotective. 1 ya nuna tasiri mai amfani a cikin samfurin linzamin kwamfuta na cutar Alzheimer. 2-methoquinone yana kare ƙwayoyin beta na pancreatic daga damuwa na iskar oxygen kuma yana inganta haɓakar insulin. 3 cell permeability. Methanesulfonate (Cat # 10-3914) da kuma Methanesulfonate cyclodextrin hadaddun (Cat # 10-3915) kuma ana iya bayar da su.

Mitoquinone, wanda kuma aka sani da MitoQ, wani nau'i ne na musamman na coenzyme Q10 (CoQ10) wanda aka tsara musamman don niyya da tarawa a cikin mitochondria, gidajen wutar lantarki na sel. Ba kamar antioxidants na gargajiya ba, waɗanda za su iya samun wahalar shiga cikin mitochondrial membrane, mitochondrial quinones an ƙera su don isa ga wannan muhimmin sashin jiki yadda ya kamata, inda suke yin tasirin antioxidant mai ƙarfi. Don haka, menene ya sa mitocone ya bambanta da sauran antioxidants? Makullin shine ikonsa kai tsaye don yaƙar damuwa na oxyidative a cikin mitochondria, inda aka samar da mafi yawan radicals masu cutarwa. Ta hanyar kawar da waɗannan radicals masu kyauta a tushen su, mitochondrial quinones suna taka muhimmiyar rawa wajen kare aikin mitochondrial da lafiyar salula gaba ɗaya. Mitochondrial quinones suna kai hari ga mitochondria ta hanyar haɗa kai da lipophilic triphenylphosphine cations. Saboda babban yuwuwar yuwuwar mitochondrial, cations suna tarawa har zuwa sau 1,000 a cikin mitochondria ta salula fiye da antioxidants marasa niyya kamar CoQ ko analogues ɗin sa, yana barin ƙwayar antioxidant don toshe peroxidation na lipid kuma yana kare mitochondria An Kare daga lalacewar oxidative. Ta hanyar zaɓin toshe lalacewar oxidative ga mitochondria, yana hana mutuwar kwayar halitta.Daga lafiyar zuciya da jijiyoyin jini zuwa cututtukan neurodegenerative, mitocone ya nuna yuwuwar sa don rage lalacewar oxidative da kuma tallafawa farfadowar tantanin halitta.

Farashin FOB:US 5-2000 / KG

Yawan Oda Min.1 KG

Ikon bayarwa:10000 KG/ wata

Port:Shanghai/Beijing

Sharuɗɗan Biyan kuɗi:L/C,D/A,D/P,T/T,O/A

Sharuɗɗan jigilar kaya:Ta teku/Ta hanyar iska/Ta hanyar Courier

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Cikakken Bayani

Tags samfurin

Sunan samfur:Mitoquinone

Wani Suna: Mito-Q; MitoQ;47BYS17IY0;

UNII-47BYS17IY0;

Mitoquinonecation;

Mitoquinone ion;

triphenylphosphanium;

MitoQ; MitoQ10;

10- (4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl) decyl-;

CAS No:444890-41-9

Musamman: 98.0%

Launi: Brown foda tare da halayyar wari da dandano

Matsayin GMO: GMO Kyauta

Shiryawa: a cikin 25kgs fiber ganguna

Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi

Rayuwar Shelf: watanni 24 daga ranar samarwa

Mitoquinone (MitoQ) Bayanin Samfur
CAS#:444890-41-9| Tsafta: ≥99% | Adana: -20°C

Bayanin Samfura

Mitoquinone (MitoQ) wani antioxidant ne wanda aka yi niyya na mitochondria wanda aka samo daga ubiquinone (CoQ10), an haɗa shi da haɗin gwiwa tare da cation na lipophilic triphenylphosphonium (TPP). Wannan tsari na musamman yana bawa MitoQ damar tara ɗaruruwan lokuta a cikin mitochondria, musamman kawar da nau'in iskar oxygen mai aiki (ROS) da kariya daga lalacewar iskar oxygen.

Mabuɗin Siffofin

Tsarin Aiki
- Isar da Niyya: TPP cation yana haifar da tarawa a cikin mitochondria, yana haɓaka kariya daga haɓakar mitochondrial ROS.
- Ayyukan Redox: MitoQ's ubiquinone moiety an rage zuwa ubiquinol, rayayye scavenging free radicals da kuma maido da mitochondrial membrane m.
Fa'idodin da aka tabbatar a cikin Bincike
- Kariyar Hanta: Yana rage danniya oxidative na hanta, kumburi, da fibrosis a cikin nau'ikan cirrhotic.
- Neuroprotection: Yana haɓaka aikin mitochondrial a cikin samfuran cututtukan Alzheimer da Parkinson, yana rage mutuwar neuronal, kuma yana haɓaka aikin motsa jiki.
- Effects na Cardiometabolic: Yana rage juriya na insulin da ke haifar da lipid kuma yana haɓaka homeostasis na glucose a ƙarƙashin damuwa na oxidative.
A cikin Vivo & In Vitro Tasirin
- Sassaucin Sashin: Mai tasiri a cikin nazarin dabba a 5-10 mg / kg (intrapereritoneal) da 25-100 mg / kg (na baka).
- Pharmacokinetics na ɗan adam: Abun da aka sha da baki tare da ƙididdigar tsoka mai iya ganowa (Cmax: ~ 3.84 µmol / g) a amintattun allurai (160 MG).

Ƙayyadaddun samfur

Form: m/Foda
Tsafta: ≥99% (tabbatar HPLC/NMR)
Adana: -20 ° C (barga don shekaru 3 a cikin foda; DMSO mafita: -80 ° C na ≤3 watanni) .
Marufi: 1 MG, 5 MG, 10 MG (akwai umarni na al'ada)

Aikace-aikace

Wuraren Bincike:
- Cututtukan Neurodegenerative: Yana rage raunin mitochondrial a cikin Parkinson's da samfuran Alzheimer.
- Fibrosis na hanta: Yana rage kumburin hanta da lalacewar oxidative.
- Rikicin Metabolic: Yana haɓaka haɓakar insulin a ƙarƙashin damuwa na lipid.
- Kariya na Zuciya: Yana rage raunin ischemia-reperfusion da rashin aiki na endothelial.
Samfuran Gwaji:
- Layukan salula (misali, SH-SY5Y, HK-2) da ƙirar dabba (mice, beraye) .

Tsaro & Biyayya

Don Amfani da Bincike kawai: Ba a yi niyya don amfanin mutum ko na asibiti ba.
Karɓa: Yi amfani da kayan kariya na sirri (safofin hannu, rigar lab); kauce wa shakar numfashi ko lamba kai tsaye .
Solubility: An ba da shawarar a cikin DMSO (maganin hannun jari barga a -20 ° C) .

Me yasa Zabi MitoQ ɗinmu?

Babban Tsarkakewa: Kula da ingancin inganci yana tabbatar da ≥99% tsabta ta hanyar TLC da NMR.
Samar da Duniya: Akwai daga masu samarwa da yawa (misali, XAQYBIO, GLPBIO, MedChemExpress) tare da jigilar kaya da sauri.
Tallafin Kimiyya: An kawo a cikiYanayi,Cell, kumaJaridar Nanobiotechnologydon ingantaccen ingantaccen gwaji.

Mahimman kalmomi

Mitochondria-niyya antioxidant, MitoQ, CAS 444890-41-9, oxidative danniya, neuroprotection, hanta fibrosis, insulin juriya, ROS scavenger, CoQ10 derivative.

Na baya: N-Boc-O-Benzyl-D-serine

Na gaba: Trigonelline HCI foda