Sunan samfur: Celastrol babban foda
Tushen Botanical: The God Vine (Tripterygium wilfordii ƙugiya.f)
CASNo:34157-83-0
Launi: Jajayen lemu crystal foda tare da siffa mai kamshi da dandano
Musammantawa: ≥98% HPLC
GMOMatsayi: GMO Kyauta
Shiryawa: a cikin 25kgs fiber ganguna
Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi
Rayuwar Shelf: watanni 24 daga ranar samarwa
Celasttrol Fodashine kayan aiki mai aiki a cikin Tripterygii Radix, wanda shine busassun tushe da rhizome na Allah Vine.Akwai jinsin hudu a duka, watoTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, da Tripterygium forresti Dicls.
Diterpenoids: triptolide (cas no.38748-32-2), Tripdiolide (cas no.38647-10-8), da dai sauransu.
Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), da dai sauransu.
Alkaloids: Wilforgine (cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, da dai sauransu.
Tripterygium shine pentazine triterpene wanda aka samo ta halitta a cikin Tripterygium wilfordii.Yana da tasiri wajen magance cututtuka na rheumatoid.Triptolide yana hana proteasome da makaman nukiliya Kb yin aiki.
Celastrol (Tripterin) shine mai hana proteasome tare da ayyukan anti-mai kumburi da antioxidant.Yana da kyau kuma zai fi dacewa yana hana ayyukan chymotrypsin-kamar na 20S proteasome tare da IC50 na 2.5 μM.
Tripterine ne mai karfi antioxidant da anti-mai kumburi wakili.Yana da sabon mai hanawa HSP90 (yana rushe hadaddun Hsp90 / Cdc37), yana da tasirin maganin ciwon daji (anti-angiogenesis - yana hana maganganun haɓakar haɓakar haɓakar ƙwayoyin cuta na jijiyoyi);antioxidant (yana hana lipid peroxidation) da aikin anti-mai kumburi (Hana samar da iNOS da cytokines mai kumburi)
BiologicalArawar jiki:
Celastrol (Tripterin) yana sarrafa basal da DNA-lalacewa wakili-induced FANCD2 monoubiquitation, biye da lalatawar furotin.Maganin Celastrol yana kawar da IR-induced G2 checkpoint kuma yana haɓaka lalacewar DNA da ke haifar da miyagun ƙwayoyi na ICL da tasirin hanawa akan ƙwayoyin cutar kansa ta huhu ta hanyar rage FANCD2.Celastrol yana da mahimmancin inhibitory da apoptosis-inducing effects a kan DU145 Kwayoyin al'ada in vitro a cikin lokaci- da kashi-dogara hanya.Celastrol ta anti-prostate ciwon daji ta hanyar rage-kayyade matakin magana na hERG tashoshi a cikin DU145 Kwayoyin, bayar da shawarar cewa Celastrol na iya zama m anti-prostate ciwon daji magani, da kuma tsarin na iya zama toshe hERG tashoshi.Celastrol yana inganta colitis na gwaji a cikin IL-10-rashin beraye ta hanyar hana hanyar siginar PI3K/Akt/mTOR da haɓaka autophagy.Celastrol yana da yuwuwar hana ayyukan cytochrome P450 kuma yana iya haifar da hulɗar ganye.Celastrol yana haifar da apoptosis a cikin ƙwayoyin TNBC, yana ba da shawarar cewa apoptosis na iya yin sulhu ta hanyar rashin aikin mitochondrial da kuma hanyar siginar PI3K/Akt.Celastrol yana haifar da apoptosis da autophagy ta hanyar siginar ROS/JNK.Celastrol yana hana mutuwar dopaminergic neuron a cikin cutar Parkinson ta hanyar kunna apoptosis mitochondrial.
Matsayin Celasttrol a cikin chemosensitization na ciwon daji:
Chemotherapy ya kasance babban zaɓin magani ga masu ciwon daji.Koyaya, sau da yawa dole ne a haɗa chemotherapy tare da wasu magunguna don rage mummunan sakamako da kuma guje wa juriya na ƙwayoyi.Ana ƙara amfani da samfuran halitta azaman hanyoyin kwantar da hankali a haɗe tare da tsarin chemotherapy da ake da su don haɓaka ingancin jiyya.Misali ɗaya mai ban sha'awa na irin wannan magani na halitta shine fili mai triterpene da ake kira celastrol, wanda zai iya samun babban yuwuwar amfani da shi azaman ji na sinadari.Asalin da aka gano daga Thunder God Vine, yana da mummunar daidaita ƙwayoyin oncogenic da yawa kamar NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, da Notch-1.Wadannan zasu iya haifar da amsawar anti-mai kumburi, hana ci gaban tumo da rayuwa, da kuma kawar da angiogenesis.Wannan babin a taƙaice yana taƙaita yuwuwar rawar celastrol a matsayin chemosensitizer da tushen tsarin kwayoyin da ke yin sulhu da rahotannin tasirin chemosensitizing a cikin cututtukan daji daban-daban.
