Sunan samfur:Wogonin Bulk Powder

Tushen Botanic: Scutellaria baicalensis

CAS No:632-85-9

Wani Suna: Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Ƙayyadaddun bayanai: ≥98% HPLC

Launi: Yellow foda tare da halayyar wari da dandano

Matsayin GMO: GMO Kyauta

Shiryawa: a cikin 25kgs fiber ganguna

Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi

Rayuwar Shelf: watanni 24 daga ranar samarwa

Scutellaria baicalensis ya ƙunshi nau'o'in sinadarai iri-iri, kamar flavonoids daban-daban, diterpenoids, polyphenols, amino acids, mai canzawa, sterol, benzoic acid, da sauransu.Tushen busassun ya ƙunshi nau'ikan flavonoids fiye da 110 kamar baicalin, baicalein, wogonoside, da wogonin, waɗanda sune babban sinadari na Scutellaria baicalensis.Daidaitaccen tsantsa kamar 80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, da 5% -98% HPLC Wogonin

A cikin Ayyukan Vitro: Wogonin yana hana PMA-induced COX-2 gene magana ta hana c-Jun magana da AP-1 kunnawa a cikin A549 Kwayoyin[1].Wogonin shine mai hana cyclin-dogara kinase 9 (CDK9) kuma yana toshe phosphorylation na yankin carboxy-terminal na RNA polymerase II a Ser.Don haka, yana rage haɓakar RNA kuma daga baya saurin raguwar ƙwayar cutar sankarar ƙwayar cuta ta myeloid cell 1 (Mcl-1) na ɗan gajeren lokaci na anti-apoptotic wanda ke haifar da shigar da apoptosis a cikin ƙwayoyin kansa.Wogonin yana ɗaure kai tsaye zuwa CDK9, mai yiwuwa ga aljihun ATP mai ɗauri kuma baya hana CDK2, CDK4 da CDK6 a allurai waɗanda ke hana ayyukan CDK9.Wogonin ya fi dacewa yana hana CDK9 a cikin m idan aka kwatanta da lymphocytes na al'ada.Wogonin kuma shine ƙwaƙƙwaran anti-oxidant mai iya ɓata ?O2?[2].Wogonin yana hana jujjuyawar NFATc1 daga cytoplasm zuwa tsakiya da aikin kunnawa na rubutu.Hakanan yana hana bambance-bambancen osteoclast kuma yana rage rubutun osteoclast?haɗe da immunoglobulin?kamar mai karɓa, tartrate?resistant acid phosphatase da mai karɓar calcitonin[4].Wogonin Yana Hana Ayyukan N-acetyltransferase

A cikin Ayyukan Vivo: Wogonin yana hana haɓakar cutar kansar ɗan adam xenografts a cikin vivo.A allurai masu kisa ga ƙwayoyin ƙari, wogonin yana nuna babu ko kaɗan mai guba ga sel na yau da kullun kuma ba shi da wani takamaiman guba a cikin dabbobi[2].Wogonin na iya haifar da apoptosis a cikin murine sarcoma S180 don haka ya hana ci gaban ƙari duka a cikin vitro da a vivo[3].Allurar intraperitoneal na 200 mg/kg Wogonin na iya hana cutar sankarar bargo da ƙwayoyin CEM gaba ɗaya.

Gwajin kwayoyin halitta:

Kwayoyin A549 al'adu ne a cikin farantin rijiyar 24 (1.2 × 105 Kwayoyin / rijiya) 1 rana kafin maganin wogonin.Ana ƙara DMSO ko wogonin cikin ƙwayoyin A549 1 h kafin haɓakar PMA, kuma ana shigar da sel don wani 6 h.Ana tattara kwayoyin halitta ta hanyar maganin trypsin kuma ana ƙidaya lambobin tantanin halitta ta hanyar amfani da hemocytometer da hanyar cirewa blue trypan.